Breast Cancer Essay Example | Topics and Well Written Essays - 1250 words - 2

Breast Cancer - Essay prototypeWhen transcription is not sufficiently balanced, it becomes detrimental to the cell and skunk cause cancer (Cox & Goding, 1991). It is therefore strategic to secure a comprehensive understanding of transcription because efforts to carry out corrections to the sue can be implemented in instances when issues in the process are apparent.Discussed specifically, the first stage of the transcription process, is seen when the ribonucleic acid Polymerase-Promoter Complex would bind to the promoter gene in the deoxyribonucleic acid (Mukakami, et.al., 2001). Such binding also leads to the initiation of the RNA polymerase. The sigma protein has to be present in order for the promoter enzyme to work. Particular sequences on the non-coding strand of the DNA are considered as a signal which would start the unwinding process (Mukakami, et.al., 2001). When the process has been started, the RNA polymerase elongation enzyme thus takes over and the second stage of the transcription process manifests. ... f the transcription process or the marge stage the uracil triphosphate or the UTP is added to the RNA through a pairing with the adenine (A) nucleotide on the template DNA strand (Gnatt, et.al., 2001). A phosphodiester bond is then formed and the RNA chain is stretched to 10 nucleotides the excess diphosphate is expected to dissociate (Gnatt, et.al., 2001). A recent study in embryonic stem cells has revealed a transcription control mechanism that is pervasive and regulated by the gene c-Myc which causes cancer. This study has also ascertained a pausing step in the transcription process which regulates the expression of about 80% of genes in mammal cells (Medical News, 2010). The long-accepted perception is that DNA-binding transcription factors include the RNA polymerase Pol II to promoters in order to start absent the transcription process. Researchers now claim that additional factors for promoters stop transcription as soon as it begins its process (Medical News, 2010). This means that even as the normal cell processes are being carried out transcription already has faulty qualities. There is a need to engage the transcription process - and this can be a function of factor c-Myc. The pause- bring out role of the c-Myc is relevant in transcription because over-expression of c-Myc is seen in different tumors and the c-Mycs failure to release transcriptional pausing is associated with the increase of cancer cells (Medical News, 2010). These results from various studies are however, still not definitive.I am now implicated in investigating the relationship of the over-expression of c-Myc in causing tumors, or more particularly, breast cancer. I externalise that c-Myc has a major role in causing tumors, including breast cancer.